Lupus Foundation of America,

Oklahoma Chapter, Inc.

Definition:

Lupus is a chronic inflammatory disease that can affect various parts of the body, especially the skin, joints, blood, and kidneys.  The body’s immune system normally makes proteins called antibodies to protect the body against viruses, bacteria, and other foreign materials.  These foreign materials are called antigens.  In an autoimmune disorder such as lupus, the immune system loses its ability to tell the difference between foreign substances (antigens) and its own cells and tissues.  The immune system then makes antibodies directed against “self.”  These antibodies, called “auto-antibodies,” react with the “self” antigens to form immune complexes.  The immune complexes build up in the tissues and can cause inflammation, injury to tissues, and pain.

For most people, lupus is a mild disease affecting only a few organs.  For others, it may cause serious and even life-threatening problems.  More than 16,000 Americans develop lupus each year.  It is estimated that 500,000 to 1.5 million Americans have been diagnosed with lupus.

Who Gets Lupus?

Nine of 10 victims are women.  Lupus is two-to-three times more prevalent among African Americans, Hispanics, Asians, and Native Americans.  Lupus develops most often during the childbearing years between 15 and 44.

Only 10 percent of people with lupus will have a close relative (parent or sibling) who already has lupus or may develop lupus.  Only about 5 percent of the children born to individuals with lupus will develop the illness.

What Causes Lupus?

Lupus is NOT infectious, rare, or cancerous.  Researchers do not know what causes lupus.  While scientists believe there is a genetic predisposition to the disease, it is known that environmental factors also play a role in triggering the disease.

Some of the factors that may trigger lupus include infections, antibiotics, ultraviolet light, extreme stress, certain drugs, and hormones.  Hormonal factors may explain why lupus occurs more frequently in females than males.

How is Lupus Treated?

For the vast majority of people with lupus, effective treatment can minimize symptoms, reduce inflammation, and maintain normal bodily functions.

Treatment approaches are based on the specific needs and symptoms of each person.  Because the characteristics and course of lupus may vary significantly among individuals, it is important to emphasize that a thorough medical evaluation and ongoing medical supervision are essential to ensure proper diagnosis and treatment.

Medications are often prescribed for people with lupus, depending on which organs are involved, and the severity of involvement.  Commonly prescribed medications include Nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, corticosteroids, antimalarials, and immunomodulating drugs.

 Symptoms of Lupus

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